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Dietary Supplement Applications

Antares Vitamin E TPGS is a water-soluble form of natural vitamin E, an emulsifier, and an absorption enhancer for fat-soluble nutrients in liquid and solid dietary supplement dosages that are designed to overcome malabsorption. 

Typical Uses in Dietary Supplements:


  • Emulsifier
  • Solubilizer
  • Source of natural, water-soluble vitamin E
  • To enhance absorption and bioavailability of nutrients and natural compounds in all liquid and solid dosage formats especially for malabsorbing populations



  • aqueous-based vitamin E
  • multivitamin/mineral supplement emulsions
  • oil blends
  • nutrition drinks



  • tablets
  • powders
  • capsules
  • softgels
  • nutrition bars

Formulating Advantages of Antares Vitamin E TPGS:

  • Available in NF grade, Food Grade (FG) and non-GMO grade (SF)
  • Long history (over 50 years) of safe use
  • Versatile, functional ingredient with proven usefulness in oral (solids and liquids) supplement formulations 
  • Readily forms emulsions
  • Readily adsorbed onto powders
  • Solubilizes and/or emulsifies a wide range of water-immiscible, lipid and poorly-soluble nutrients
  • Long history (over 50 years) of safe use
  • Supplies natural d-α-tocopherol in water-soluble form. (It is universally accepted that the natural form of vitamin E, d-α-tocopherol, is more potent than the synthetic form of vitamin E, dl-α-tocopherol. This body of acceptance extends throughout industry and includes the Food and Drug Administration (FDA) and the National Academy of Sciences (NAS)). For more information on the advantages of the natural d-α- over the synthetic dl-α- tocopherol, see reference 1 below.
  • Overcomes malabsorption of vitamin E in malabsorbing patients. This benefit, reported by Dr. Sokol in cholestatic patients more than 20 years ago, was confirmed in a multicenter clinical trial (reference 2 below).
  • Enhances the absorption of lipid soluble nutrients and natural compounds in malabsorbing patients (reference 3 below).

If you need additional assistance regarding the use of Antares Vitamin E TPGS in your specific application, please Contact Us

For basic handling and use guidelines for Antares Vitamin E TPGS, see How To Use TPGS.

Download Safety Data Sheet, Product Data Sheet and additional product documentation from our Documentation page. 

Selected References:

  1. Papas A. The Vitamin E Factor. HarperCollins Publishers. New York, 1999.
  2. Sokol RJ, Butler-Simon N, Conner C, Heubi JE, Sinatra FR, Suchy FJ, Heyman MB, Perrault J, Rothbaum RJ, Levy J, et al. Multicenter trial of d-alpha-tocopheryl polyethylene glycol 1000 succinate for treatment of vitamin E deficiency in children with chronic cholestasis. Gastroenterology. 1993 Jun;104(6):1727-35.
  3. Argao EA, Heubi JE, Hollis BW, Tsang RC. d-Alpha-tocopheryl polyethylene glycol-1000 succinate enhances the absorption of vitamin D in chronic cholestatic liver disease of infancy and childhood. Pediatr Res. 1992 Feb;31(2):146-50.