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Emulsifier & Solubilizer

Antares Vitamin E TPGS has an amphiphilic molecular structure with a polar hydrophilic head (consisting of polyethylene glycol) and a non-polar lipophilic tail (consisting of the phytyl chain of d-α-tocopherol). This makes it soluble in both water and oil. In addition, it exhibits low critical micelle concentration (CMC) and creates a large total surface area of oil it disperses in water. These characteristics combined with Its physical/chemical stability in water solutions and dispersions make TPGS an effective emulsifier.

Antares Vitamin E TPGS can also solubilize a wide range of water-immiscible and other poorly soluble compounds making it an excellent carrier and diluent material for lipid ingredients.

The characteristics above coupled with its ability to form various liquid crystalline phases in water mixtures present TPGS as a useful formulation excipient for a range of liquid formulation needs. Below are some formulation characteristics of TPGS relevant to its functionality as a solubilizer and emulsifier.

Melting Point 38°C (approximate), range 37-41
Solubility In Water Miscible In All Parts
HLB (Hydrophile/Lipophile Balance) 13 (approximate)
CMC (Critical Micelle Concentration) 0.02 weight %
Particle Size Reported particle size ranges in diameter from less than 1 and up to several microns for liquid emulsions

If you need additional assistance regarding the use of Antares Vitamin E TPGS in your specific application, please Contact Us

 

For basic handling and use guidelines for Antares Vitamin E TPGS, see How To Use TPGS.

 

Download Safety Data Sheet, Product Data Sheet and additional product documentation from our Documentation page.