Bioavailability Enhancement
The Benefits Of TPGS
Antares Vitamin E TPGS is an amphiphilic molecule which encapsulates lipids and fats making them water soluble . This unique property , combined with its permeability glycoprotein (P-gp) inhibition, makes TPGS a highly effective emulsifier.
Improves Solubility and Absorption - TPGS is proven to be a safe and effective method of improving the absorption and bioavailability of poorly soluble materials through the formation of micelles and the modulation of the efflux pump through P-gp inhibition.
Facilitates Permeation - TPGS facilitates the permeation of a variety of cellular membranes, including those in the gut, mouth, eyes, and skin.
Inhibits P-gp Efflux System - In the gut, malabsorption can be caused by the rejection of certain compounds by the cellular efflux pump , which is controlled by permeability glycoproteins (P-gp). Formulas enhanced by TPGS inhibit P-gp from this rejection, thus improving absorption through the gut wall.
Supports Drug Delivery - Multi-Drug Resistance (MDR) lowers the efficacy of many substances, but TPGS can combat MDR by acting as a P-gp inhibitor , significantly increasing the intracellular accumulation of co-formulated therapeutic agents.
Industries That Benefit From Bioavailability Enhancement & Research
Antares Vitamin E TPGS, also known as tocophersolan, is used in various applications from an emulsifier in cosmetics to a solubilizer in drugs and dietary supplements. It can also act as an absorption and permeation enhancer. Many industries benefit from the bioavailability, solubility and research of this self-emulsifying drug delivery system (SEDDS), including the following: