DIETARY SUPPLEMENT ABSORPTION

Antares Vitamin E TPGS is a water-soluble form of natural vitamin E and functions as an enhancer of absorption and bioavailability of poorly soluble dietary supplements. Antares Vitamin E TPGS is a water-soluble form of natural vitamin E which enhances the absorption and bioavailability of poorly soluble dietary supplements. In addition to increasing the solubility of lipophilic materials through emulsification, vitamin E TPGS enhances/promotes bioavailability by inhibiting the P-glycoprotein efflux pump in the digestive tract. TPGS improves the delivery of a wide variety of dietary supplements in both liquid and solid formulations, and is therefore a powerful tool in the treatment of malabsorption.

Common Uses in Dietary Supplements:

FORMULATION AID

  • Emulsifier

  • Solubilizer

  • Source of natural, water-soluble vitamin E

  • Designed/Used to enhance absorption and bioavailability of nutrients and natural compounds in all liquid and solid dosage formats, especially for malabsorbing populations[1] 

 LIQUID DOSAGES

  • Aqueous-based vitamin E

  • Multivitamin/mineral supplement emulsions

  • Oil blends

  • Nutrition drinks

SOLID DOSAGES

  • Tablets

  • Powders

  • Capsules

  • Softgels

  • Nutrition bars

Formulating Advantages of Antares Vitamin E TPGS:

  • Available in multiple grades including NF, FG, and non-GMO Sunflower TPGS™ (NF and FG)

  • Long history (over 50 years) of safe use

  • Versatile, functional ingredient with proven usefulness/effectiveness in oral (solids and liquids) supplement formulations

  • Readily forms emulsions

  • Readily blends with powders

  • Solubilizes and/or emulsifies a wide range of water-immiscible, lipid and poorly-soluble nutrients

  • Supplies natural d-α-tocopherol in water-soluble form. It is universally accepted that the natural form of vitamin E, d-α-tocopherol, is more potent than its synthetic duplicate , dl-α-tocopherol. This acknowledgement  extends throughout industry, including the Food and Drug Administration (FDA) and the National Academy of Sciences (NAS). For more information on the advantages of the natural d-α- over the synthetic dl-α- tocopherol, see reference 1 below.

  • Overcomes malabsorption of vitamin E in malabsorbing patients. This benefit, reported by Dr. Sokol in cholestatic patients more than 20 years ago, was confirmed in a multicenter clinical trial (reference 2 below).

  • Enhances the absorption of lipid soluble nutrients and natural compounds in malabsorbing patients (reference 3 below). As the recognized leader in producing this form of water-soluble vitamin E, Antares has the expertise and capabilities to work successfully with pharmaceutical companies as well as R&D labs, nutraceutical producers, cosmetics manufacturers, and more. Our formulations are made to the highest standards of quality. To learn more about how we can make something for your product line, get in touch with us today.

If you need additional assistance regarding the use of Antares Vitamin E TPGS in your specific application, please contact us. For basic handling and use guidelines for Antares Vitamin E TPGS, see How To Use TPGS. Download Safety Data Sheet, Product Data Sheet and additional product documentation from our Documentation page. 

Selected References:

  1. Papas A. The Vitamin E Factor. HarperCollins Publishers. New York, 1999.

  2. Sokol RJ, Butler-Simon N, Conner C, Heubi JE, Sinatra FR, Suchy FJ, Heyman MB, Perrault J, Rothbaum RJ, Levy J, et al. Multicenter trial of d-alpha-tocopheryl polyethylene glycol 1000 succinate for treatment of vitamin E deficiency in children with chronic cholestasis. Gastroenterology. 1993 Jun;104(6):1727-35.

  3. Argao EA, Heubi JE, Hollis BW, Tsang RC. d-Alpha-tocopheryl polyethylene glycol-1000 succinate enhances the absorption of vitamin D in chronic cholestatic liver disease of infancy and childhood. Pediatr Res. 1992 Feb;31(2):146-50.