CHEMICAL PROPERTIES OF VITAMIN E TPGS

Antares Vitamin E TPGS is the polyethylene glycol 1000 ester of d-α-tocopheryl succinate. It is chemically stable to heat, oxygen and light.

Chemical Name - d-α-tocopheryl polyethylene glycol 1000 succinate

Empirical Formula - C3305H54(CH2 CH2O)n

Synonyms & Acronyms - Vitamin E TPGS or TPGS Tocophersolan (International Nomenclature of Cosmetic Ingredients – INCI and United States Adopted Names - USAN). INCI VITAMIN E.

CAS Number - 9002-96-4

Vitamin E TPGS Molecular Weight - 1513 (approximately)

d-α-tocopherol - 25% minimum weight basis

Acid Value - Not more than 0.27 ml/g

PHYSICAL PROPERTIES OF TPGS

Antares Vitamin E TPGS is a white to light tan water-soluble waxy solid with low melting point.

Physical Form - Waxy solid

Color - White to light tan (as solid)

Gardner Color - Less than 10 (generally less than 5)

Specific Gravity - 1.06 at 45 °C (approximate)

Melting Point - 38 °C (approximate), range 37-41 °C

Solubility In Water - Soluble in water at 20 wt %

Specific Rotation [α] - Not less than +24°

AMPHIPHILIC (SURFACE-ACTIVE) PROPERTIES

Antares Vitamin E TPGS has amphiphilic properties with each molecule consisting of polar hydrophilic (polyethylene glycol) and non-polar lipophilic (phytyl chain of d-α-tocopherol) moieties. 

HLB (Hydrophile Lipophile Balance) - 13 (approximate)

CMC (Critical Micelle Concentration) - 0.02 weight %

Particle Size - Reported particle size diameter ranged from less than 1 and up to several microns for stable liquid emulsions